Abstract Concomitant chromatin assembly and DNA duplication is essential for cell survival and genome integrity, and requires newly synthesized histones.Although the N-terminal domains of newly synthesized H3 and Kettle Lead H4 present critical functions, their requirement for replication-coupled chromatin assembly is controversial.Using the unique
Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation.It is noteworthy that an accumulating body of in vivo and in vitro evidence links these channels to multiple sclerosis pat
Future global climate change with higher mean temperatures and increased intensity and frequency of heatwaves as extreme weather events will affect aquatic ecosystems with, yet, unpredictable severity and consequences.Although Wind Jacket models suggest increased risk of species extinction up to the year 2050 for series of different climate change
Background: The estimated number of refugees worldwide resulting from persecution, conflict, violence, or human rights violations reached 25.4 million in 2017.An increased prevalence of mental disorders combined with language and socio-cultural barriers pose a challenge for healthcare systems.Internet-based interventions can help to meet this chall
Abstract For places where non-sterile drug production occurs, regulatory bodies recommend monitoring of the environmental bioburden.This procedure provides information regarding possible microbiological risks to which the products may be exposed, so that subsequent action measures may be implemented.The aim of the present work was to quantify and c